Sermorelin
A GHRH analog that prompts the pituitary to release growth hormone—often stacked with GHRP peptides in clinic and research conversations.
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✨ real molecule sketch
See this name online?
Sermorelin
Fitness peptides are often sold for “research use”—learn the compound before trusting a label.
Pharmacokinetic snapshot
Reference values from published sources—not prescribing or dosing advice. Cosmetic INCI peptides do not belong here; injectable and prescription contexts only.
- Half-life
- ~12 min
- Typical dose range
- 150–500 mcg
- Common frequency
- Often nightly (unapproved off-label)
Source: PubMed sermorelin
Structure (cute edition)
✨ real molecule sketch
This peptide is a short chain of about 4 amino acids—think of it as a tiny protein necklace on your label.
INCI: Sermorelin · ~4 amino acids in our simplified view
Research & public records
Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.
Knowledge base: pharmaceutical drug — Wikipedia
PubMed: 174 indexed papers (search PubMed)
- Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples. · Analytical biochemistry
- An immuno polymerase chain reaction screen for the detection of CJC-1295 and other growth-hormone-releasing hormone analogs in equine plasma. · Drug testing and analysis
- Glycine-modified growth hormone secretagogues identified in seized doping material. · Drug testing and analysis
- Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC1 receptors. · Hippocampus
- Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission. · Hippocampus
- Site-specific PEGylation for high-yield preparation of Lys(21)-amine PEGylated growth hormone-releasing factor (GRF) (1-29) using a GRF(1-29) derivative FMOC-protected at Tyr(1) and Lys(12). · Bioconjugate chemistry
- Interactions of GRF(1-29)NH2 with plasma proteins and their effects on the release of the peptide from a PLAGA matrix. · Journal of controlled release : official journal of the Controlled Release Society
- Chromatographic separation and mass spectrometric identification of positional isomers of polyethylene glycol-modified growth hormone-releasing factor (1-29). · Journal of chromatography. A
Clinical trials: 42 studies on ClinicalTrials.gov (view search)
- Diagnosing Adult Growth Hormone Deficiency · COMPLETED
- Effects of Triptorelin When Given Every 6-months Under the Skin to Adult Males With Cancer in the Prostate · COMPLETED
- A Study of GDC-0810 Single Agent or in Combination With Palbociclib and/or a Luteinizing Hormone-Releasing Hormone (LHRH) Agonist in Women With Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer · TERMINATED
- Bay98-7196, Dose Finding / POC Study · COMPLETED
- A Phase 3 Study to Evaluate the Efficacy and Safety of Relugolix (TAK-385) 40 mg Compared With Leuprorelin in the Treatment of Uterine Fibroids · COMPLETED
- Pharmacokinetics and Pharmacogenomics of Ribociclib in Race-based Cohorts · TERMINATED
- GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer Patients · RECRUITING
- A Short-term Preoperative, Evaluating Activity and Safety of Elacestrant Monotherapy as Compared to Elacestrant + Ovarian Function Suppression (LHRH Agonist) in Premenopausal Patients With Stage I-II ER+/HER2- Breast Cancer · RECRUITING
ChEMBL: SERMORELIN ACETATE · max phase 4.0
DailyMed labels: 1 SPL
What brands say it does
Sermorelin mimics the first 29 amino acids of growth-hormone-releasing hormone. It stimulates pulsatile GH release rather than supplying GH directly. It was FDA-approved as a diagnostic (Geref) but is widely discussed off-label for anti-aging and recovery protocols. Human data for cosmetic or athletic use is limited.
Where you’ll find it
Anti-aging clinics, telehealth peptide programs, and research suppliers—not drugstore supplements.
Other names you might see
GRF 1-29
GHRH 1-29
Sermorelin acetate
Compare with similar peptides
Similar peptides
Educational only—not medical advice. Many compounds here are banned in sport and not FDA-approved for OTC use.