MOTS-c
A mitochondrial-derived peptide studied for exercise mimetic and metabolic effects.
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✨ real molecule sketch
See this name online?
Mitochondrial open reading frame peptide
Fitness peptides are often sold for “research use”—learn the compound before trusting a label.
Structure (cute edition)
✨ real molecule sketch
This peptide is a short chain of about 4 amino acids—think of it as a tiny protein necklace on your label.
INCI: Mitochondrial open reading frame peptide · ~4 amino acids in our simplified view
Research & public records
Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.
Knowledge base: peptide encoded in mitochondrial DNA — Wikipedia
PubMed: 243 indexed papers (search PubMed)
- Reduced Circulating MOTS-c Levels in Hashimoto's Thyroiditis Reflect Integrated Autoimmune and Metabolic Dysregulation: A Cross-Sectional Study. · Journal of clinical medicine
- MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia. · Frontiers in medicine
- MOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases. · Journal of translational medicine
- MOTS-c preserves mitochondrial subpopulation bioenergetics and genome integrity to attenuate cardiac ischemia reperfusion injury. · Molecular biology reports
- Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction. · Biomedicines
- Elevated Serum Nardilysin Is Inversely Associated with Cardiovascular Disease in Kidney Transplant Recipients. · Kidney & blood pressure research
- MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation. · Autophagy
- LAT1-mediated delivery of engineered R13A-MOTS-c attenuates radiation-induced lung injury via Nrf2 activation and mitochondrial protection. · Redox biology
Clinical trials: 172 studies on ClinicalTrials.gov (view search)
- Exercise Post-Diagnosis of Breast Cancer · COMPLETED
- MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity · RECRUITING
- Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding · NOT_YET_RECRUITING
- Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD · UNKNOWN
- Long Term Outcomes After Vestibular Implantation · RECRUITING
- Cohort Of DEafness-gene Screening · ACTIVE_NOT_RECRUITING
- The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination · RECRUITING
- Analysis of Effects of High-intensity Physical Exercise in Subjects With Dialyzed Chronic Kidney Disease and in Conservative Treatment · RECRUITING
ChEMBL: CHEMBL3350556
What brands say it does
MOTS-c is encoded in mitochondrial DNA and regulates glucose and fatty acid metabolism. Mouse studies show improved exercise capacity and insulin sensitivity. Human trials are emerging; longevity clinics have begun offering it experimentally.
Where you’ll find it
Longevity clinics, exercise science research, and cutting-edge wellness protocols.
Other names you might see
Mitochondrial open reading frame peptide
Mitochondrial peptide
Compare with similar peptides
Educational only—not medical advice. Many compounds here are banned in sport and not FDA-approved for OTC use.