MOTS-c
A mitochondrial-derived peptide studied for exercise mimetic and metabolic effects.
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✨ real molecule sketch
See this name online?
Mitochondrial open reading frame peptide
Fitness peptides are often sold for “research use”—learn the compound before trusting a label.
Pharmacokinetic snapshot
Reference values from published sources—not prescribing or dosing advice. Cosmetic INCI peptides do not belong here; injectable and prescription contexts only.
- Half-life
- ~12 hours (est.)
- Typical dose range
- 2.5–10 mg
- Common frequency
- Often 3×/week in protocols (investigational)
Source: PubMed MOTS-c
Structure (cute edition)
✨ real molecule sketch
This peptide is a short chain of about 4 amino acids—think of it as a tiny protein necklace on your label.
INCI: Mitochondrial open reading frame peptide · ~4 amino acids in our simplified view
FDA label data
Sourced from OpenFDA drug labels (public domain). Not medical advice.
Brand names: MDP PEPTIDE 9 BIO SUN PRO, MDP UV BIO SUNSCREEN
Manufacturer: SKINIDEA CO., LTD
Indications
Use(s) ■ Helps prevent sunburn ■ If used as directed with other sun protection measures (see Directions), decreases the risk of skin cancer and early skin aging caused by the sun
Warnings
Warnings ■ For external use only.
Research & public records
Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.
Knowledge base: peptide encoded in mitochondrial DNA — Wikipedia
PubMed: 246 indexed papers (search PubMed)
- Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy. · Experimental physiology
- Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human mesenchymal stromal cells. · Inflammation and regeneration
- Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model. · Experimental physiology
- Reduced Circulating MOTS-c Levels in Hashimoto's Thyroiditis Reflect Integrated Autoimmune and Metabolic Dysregulation: A Cross-Sectional Study. · Journal of clinical medicine
- MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia. · Frontiers in medicine
- MOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases. · Journal of translational medicine
- MOTS-c preserves mitochondrial subpopulation bioenergetics and genome integrity to attenuate cardiac ischemia reperfusion injury. · Molecular biology reports
- Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction. · Biomedicines
Clinical trials: 174 studies on ClinicalTrials.gov (view search)
- MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity · RECRUITING
- Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD · UNKNOWN
- Cohort Of DEafness-gene Screening · ACTIVE_NOT_RECRUITING
- The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination · RECRUITING
- Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding · NOT_YET_RECRUITING
- Long Term Outcomes After Vestibular Implantation · RECRUITING
- Exercise Post-Diagnosis of Breast Cancer · COMPLETED
- Analysis of Effects of High-intensity Physical Exercise in Subjects With Dialyzed Chronic Kidney Disease and in Conservative Treatment · RECRUITING
ChEMBL: CHEMBL3350556
DailyMed labels: 2 SPLs
What brands say it does
MOTS-c is encoded in mitochondrial DNA and regulates glucose and fatty acid metabolism. Mouse studies show improved exercise capacity and insulin sensitivity. Human trials are emerging; longevity clinics have begun offering it experimentally.
Where you’ll find it
Longevity clinics, exercise science research, and cutting-edge wellness protocols.
Other names you might see
Mitochondrial open reading frame peptide
Mitochondrial peptide
Compare with similar peptides
Similar peptides
Educational only—not medical advice. Many compounds here are banned in sport and not FDA-approved for OTC use.