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TB-500

Recovery

A synthetic version of thymosin beta-4 marketed for soft-tissue repair and flexibility.

Updated August 13, 2026 · By The Peptide Dex — Fitness Editorial

See this name online?

TB-500

Fitness peptides are often sold for “research use”—learn the compound before trusting a label.

Pharmacokinetic snapshot

Reference values from published sources—not prescribing or dosing advice. Cosmetic INCI peptides do not belong here; injectable and prescription contexts only.

Half-life: ~2 hours
Typical dose range: 250 mcg–2.5 mg
Common frequency: Varies; often 2×/week in stacks (unapproved)

Source: PubMed thymosin β4

Structure (cute edition)

✨ real molecule sketch

This peptide is a short chain of about 4 amino acids—think of it as a tiny protein necklace on your label.

INCI: TB-500 · ~4 amino acids in our simplified view

Research & public records

Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.

Knowledge base: pharmaceutical compound — Wikipedia

PubMed: 16 indexed papers (search PubMed)

Therapeutic peptides in gerontology: mechanisms and applications for healthy aging. · Frontiers in aging
Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. · Sports medicine (Auckland, N.Z.)
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians. · The American journal of sports medicine
Comparative effects of dietary sodium butyrate and tributyrin on broiler chickens' performance, gene expression, intestinal histomorphometry, blood indices, and litter. · Scientific reports
Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro. · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Adsorption effects of the doping relevant peptides Insulin Lispro, Synachten, TB-500 and GHRP 5. · Analytical biochemistry
Comparison of various in vitro model systems of the metabolism of synthetic doping peptides: Proteolytic enzymes, human blood serum, liver and kidney microsomes and liver S9 fraction. · Journal of proteomics

Clinical trials: 1 studies on ClinicalTrials.gov (view search)

TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD · RECRUITING

ChEMBL: TB-402 · max phase 2.0

What brands say it does

Thymosin beta-4 regulates actin and promotes cell migration in wound healing. TB-500 is the acetylated fragment used in research. Athletes use it for muscle tears and inflammation, but human evidence is mostly preclinical. Banned by WADA in competition.