TB-500
A synthetic version of thymosin beta-4 marketed for soft-tissue repair and flexibility.
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✨ real molecule sketch
See this name online?
TB-500
Fitness peptides are often sold for “research use”—learn the compound before trusting a label.
Structure (cute edition)
✨ real molecule sketch
This peptide is a short chain of about 4 amino acids—think of it as a tiny protein necklace on your label.
INCI: TB-500 · ~4 amino acids in our simplified view
Research & public records
Counts and links from public databases (PubMed, ClinicalTrials.gov, Wikidata, NIH drug nomenclature). Educational only — not medical advice.
Knowledge base: pharmaceutical compound
PubMed: 595 indexed papers (search PubMed)
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging. · Frontiers in aging
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. · Sports medicine (Auckland, N.Z.)
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
- Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians. · The American journal of sports medicine
- Comparative effects of dietary sodium butyrate and tributyrin on broiler chickens' performance, gene expression, intestinal histomorphometry, blood indices, and litter. · Scientific reports
- Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro. · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- Adsorption effects of the doping relevant peptides Insulin Lispro, Synachten, TB-500 and GHRP 5. · Analytical biochemistry
- Comparison of various in vitro model systems of the metabolism of synthetic doping peptides: Proteolytic enzymes, human blood serum, liver and kidney microsomes and liver S9 fraction. · Journal of proteomics
Clinical trials: 18 studies on ClinicalTrials.gov (view search)
- TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD · RECRUITING
- Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye · COMPLETED
- Study of Thymosin Beta 4 in Patients With Pressure Ulcers · COMPLETED
- A Phase 2 Study on Effect of Thymosin Beta 4 on Wound Healing in Patients With Epidermolysis Bullosa · TERMINATED
- Study of Thymosin Beta 4 in Patients With Venous Stasis Ulcers · COMPLETED
- Recombinant Human Thymosin Beta 4 for Injection(NL005) for Acute Myocardial Infarction · NOT_YET_RECRUITING
- Safety and Efficacy Study of Thymosin Beta 4 in Patients With Acute Myocardial Infarction.Infarction · COMPLETED
- A Phase 1a Study of Thymosin Beta 4 in Healthy Volunteers · COMPLETED
ChEMBL: TB-402 · max phase 2.0
What brands say it does
Thymosin beta-4 regulates actin and promotes cell migration in wound healing. TB-500 is the acetylated fragment used in research. Athletes use it for muscle tears and inflammation, but human evidence is mostly preclinical. Banned by WADA in competition.
Where you’ll find it
Recovery peptide stacks, equine medicine (where legal), and research vendors.
Other names you might see
Thymosin Beta-4
Tβ4
Thymosin β-4 fragment
Compare with similar peptides
Educational only—not medical advice. Many compounds here are banned in sport and not FDA-approved for OTC use.